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Project Code

2025_033

Start date

1 October 2026

Primary supervisor

Professor Angus Roberts

Secondary supervisor

Professor Cathryn Lewis

Topic Areas

EHRs, NLP, and LLMs

Co-Funded

Leveraging Electronic Health Records and Genetic Data for Personalized Antidepressant Treatment

Background

Antidepressants are among the most commonly prescribed medications for depression, yet many patients experience variable or incomplete treatment responses. Identifying why individuals respond differently remains a major challenge in mental health research and clinical care. Current evidence is often limited by short follow-up periods, narrow clinical data, and insufficient integration of biological and environmental factors. Advances in health data science and genomics now provide an opportunity to better understand the determinants of treatment outcomes at scale.

Novelty & Importance

This project will take a comprehensive, data-driven approach to investigate antidepressant treatment trajectories using linked electronic health records (EHRs) and genetic data. By combining primary care data from the Clinical Practice Research Datalink (CPRD) with the UK Biobank, the study will analyse large-scale longitudinal data enriched with genetic, clinical, and environmental information. Natural language processing (NLP) techniques will unlock insights from unstructured text, while secondary care EHRs will be used to validate findings—clarifying whether treatment switching reflects lack of efficacy, side effects, or adherence issues. This integrated, multimodal approach goes beyond existing studies, enabling more precise modelling of individual differences in antidepressant response.

Aims & Objectives

The project aims to identify the clinical, environmental, and genetic factors that shape antidepressant treatment outcomes. Specifically, it will:

1. Build a comprehensive longitudinal dataset of antidepressant prescribing trajectories linked to genetic and phenotypic data.

2. Develop algorithmic and NLP pipelines (e.g., large language models) to measure treatment response, resistance, and switching behaviours.

3. Validate findings using secondary care records to better understand the drivers of switching and nonresponse.

4. Apply advanced causal inference methods to identify factors that directly influence outcomes.

This research will generate new evidence to support more personalised and effective antidepressant prescribing, improving care for people living with depression.

We are now accepting applications for 1 October 2026

How to apply

Candidates should possess or be expected to achieve a 1st or upper 2nd class degree in a relevant subject including the biosciences, computer science, mathematics, statistics, data science, chemistry, physics, and be enthusiastic about combining their expertise with other disciplines in the field of healthcare.

Important information for International Students:

It is the responsibility of the student to apply for their Student Visa. Please note that the EPSRC DRIVE-Health studentship does not cover the visa application fees or the Immigration Health Surcharge (IHS) required for access to the National Health Service. The IHS is mandatory for anyone entering the UK on a Student Visa and is currently £776 per year for each year of study. Further detail can be found under the International Students tab below.

How to apply

Closing date: 12 January 2026 (23:59 hrs GMT)

Create an account with King’s Apply.

Apply to the EPSRC DRIVE-Health: Centre for Doctoral Training in Data-Driven Health MPhil/PhD (Full-time).

Please ensure you read the full information required on our Apply page, particularly relating to Personal Statement and Supporting Information.

Complete the following sections of the application with all the relevant information.

A PDF copy of your CV should be uploaded to the Employment History section.
A 500-word personal statement is required outlining your motivation for undertaking postgraduate research with the CDT, and you only need to choose one way to provide it. You can either type it directly into the application form (maximum 4,000 characters) or upload it as a separate document if you have a longer statement (maximum two pages).
Please nominate up to 3 projects of particular interest by quoting the project codes in the research proposal section of the online application form.

Funding:

Please choose Option 5 “I am applying for a funding award or scholarship administered by King’s College London” in the funding section.
Under “Award Scheme Code or Name” enter “EPSRC DRIVE-Health 2026”.

Failing to include one of these codes might result in you not being considered for funding.

Questions marked * are mandatory and you will not be able to submit without answering.

Non-EU international applicants are advised that ATAS may be required. While there is no charge to apply for ATAS, processing can take up to 3 months. Please read the Important Information for International Students.

Apply Now

Funding

Enhanced Studentships to Attract Top Talent

Each studentship is fully funded for 4 years.

This includes tuition fees, a stipend and a generous allowance for project consumables.

Tuition Fees: these will be covered for both Home and International students.

Stipend: students will receive a tax-free living allowance of £25,403.40 per year (current projection for Academic Year 2026/27).

Research Training Support Grant (RTSG): up to £20,000 over 4 years for research consumables and attending national and international conferences.

International

Important Information for International Students

It is the responsibility of the student to apply for their Student Visa.

Please note that the EPSRC DRIVE-Health studentship does not cover the visa application fees or the Immigration Health Surcharge (IHS) required for access to the National Health Service. The IHS is mandatory for anyone entering the UK on a Student Visa and is currently £776 per year for each year of study.

Additionally, depending on your chosen project, some nationals may need to apply for an Academic Technology Approval Scheme (ATAS) certificate prior to applying for a visa. The ATAS application process can take up to 3 months and so it is essential that you apply for this early. Please note the following:
• If you need to apply for a student visa, you cannot submit your visa application until your ATAS certificate has been issued.
• If you are applying for any other visa, you cannot enrol at King’s and start your programme unless your ATAS certificate has been issued.
• If you apply late, you may not be able to join on the expected entry point and your registration may be postponed

Please review the following article for further information on the ATAS certificate and how to apply:Do I need ATAS clearance before I start my course at King’s?

For further advice, please contact the Visas & International Student Advice as soon as possible.

Eligibilty

Academic Requirements and Eligibility

We welcome eligible Home and International applicants from any personal background who are pleased to join diverse and friendly research groups.

Open to Home and International applicants.

Applicable level of study: Postgraduate research.

English Language Requirements (Band D)
Based on the IELTS test scoring system, this programme requires that successful candidates achieve the following level of English before enrolling. Successful applicants’ offer letters will include information about when they must have achieved this standard.
Overall: 6.5
Listening: 6
Speaking: 6
Reading: 6
Writing: 6

Visit our admissions webpages to view our English language entry requirements.

Next steps

For project-specific queries, please contact the main supervisor before you submit your application.

Applications submitted by 12 January 2026 (23:59 GMT) will be considered by the EPSRC DRIVE-Health Centre for Doctoral Training. We will contact shortlisted applicants with information about the next stage of the recruitment process.

Candidates will be invited to attend an interview. Interviews are scheduled to take place in March/April 2026.

Project selection will be through a panel interview chaired by either Professor Richard Dobson or Professor Vasa Curcin (Centre Co-Directors), followed by an informal discussion with prospective supervisors.

For any other questions about the recruitment process, please email us at drive-health-cdt@kcl.ac.uk.