AI-Driven Retrobiosynthesis for Mechanistic Discovery in Cancer and Precision Medicine

by jo.dobson@kcl.ac.uk | Dec 4, 2025

Rapid advances in omics technologies, coupled with major improvements in computational and analytical tools, have enabled the generation of high-quality, cost-efficient multi-omics data that are now driving the emergence of precision health and precision medicine...

Integrative analysis of colon tissue multi-omics with electronic health record data to investigate the role of host-microbiome interactions in human health

by luke | Dec 1, 2025

1. Background The human colon is home to trillions of microorganisms, or the gut microbiota, which affect the health of the host through complex interactions with the host. Much research is focused on identifying host-microbiome interactions in both health and...

Using machine learning to predict treatment pathways in end stage kidney disease (ESKD)

by luke | Dec 1, 2025

Background In the UK, around 10% of adults have chronic kidney disease, which is becoming more common. Some people go on to develop end stage kidney disease or kidney failure (ESKD). This affects the quality of life of those affected and increases the risk of death....

Integrative Analysis of RNA Splicing and Modifications in Amyotrophic Lateral Sclerosis

by luke | Dec 1, 2025

Background Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease marked by progressive degeneration of upper and lower motor neurons. A defining molecular feature of ALS is the widespread disruption of RNA processing, largely due to the dysfunction...

Modifiers of Methylation-Defined Health Risk Scores at Chromatin Regulator Loci

by luke | Dec 1, 2025

Background Every cell in the body contains the same DNA, yet can develop and function in highly specialised ways. A pivotal way of enabling this is through epigenetic modification, such as DNA methylation, which help mark active and inactive regions of the genome with...